1. mapped reads in BAM format

2. predicted or validated SNVs or indels in mutation annotation format (MAF)

3. a list of regions of interest (typically the boundaries of coding exons)

4. any relevant numeric or categorical clinical data.

The formats for inputs 3. and 4. are:

3. Regions of Interest File:

4. Clinical Data Files:

Descriptions for the usage of each tool (each sub-command) can be found separately.

The play command runs all of the sub-commands serially on a selected input set.

EOS }

sub _doc_copyright_years {
(2007,2011); }

sub _doc_license {
my $self = shift;
my (@y) = $self->_doc_copyright_years;
return <<EOS Copyright (C) $y[0]-$y[1] Washington University in St. Louis.

It is released under the Lesser GNU Public License (LGPL) version 3. See the associated LICENSE file in this distribution. EOS }

sub _doc_authors {
return <<EOS This software is developed by the analysis and engineering teams at The Genome Institute at Washington University School of Medicine in St. Louis, with funding from the National Human Genome Research Institute. Richard K. Wilson, P.I.

The primary authors of the MuSiC suite are:

 Nathan D. Dees, Ph.D.
 Cyriac Kandoth, Ph.D.
 Dan Koboldt, M.S.
 William Schierding, M.S.
 Michael Wendl, Ph.D.
 Qunyuan Zhang, Ph.D.
 Thomas B. Mooney, M.S.

EOS }

sub _doc_bugs {
return <<EOS; For defects with any software in the genome namespace, contact
genome-dev ~at~ genome.wustl.edu. EOS }

sub _doc_credits {
return <<EOS, The MuSiC suite uses tabix, by Heng Li. See http://samtools.sourceforge.net/tabix.shtml.

MuSiC depends on copies of data from the following databases, packaged in a form useable for quick analysis:

 * KEGG - http://www.genome.jp/kegg/
 * COSMIC - http://www.sanger.ac.uk/genetics/CGP/cosmic/
 * OMIM - http://www.ncbi.nlm.nih.gov/omim
 * Pfam - http://pfam.sanger.ac.uk/
 * SMART - http://smart.embl-heidelberg.de/
 * SUPERFAMILY - http://supfam.cs.bris.ac.uk/SUPERFAMILY/
 * PatternScan - http://www.expasy.ch/prosite/

EOS }

sub _doc_see_also {
'genome(1)', }

1;